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Please be aware that the International Institute of Physics, IIP, does not request payment information of any kind. Scammers sometimes approach participants claiming to be able to provide accommodation and asking for credit card information. Please do not give any information away. IIP will be in touch via official email regarding accommodation and financial support for qualified applicants. If you have any questions, please contact IIP events department at events@iip.ufrn.br

Overview

 

The mission of this workshop is to help building a bridge over the gap between physics, where one seeks to understand detailed properties of relatively simple systems, and biology, which studies the overall behavior of highly complex systems. A particularly interesting area where the relative simplicity of a physical system can profitably meet the complexity of life, is the study of biopolymers such as proteins, in particular the so-called protein folding problem.

 

 

A protein folding in a biological system has to be a robust process, the biological function of a protein depends critically on its three dimensional shape. Thus the goal to understand how a protein folds enables us to understand the functioning of living systems. Moreover, a wrong fold is a common cause for a protein to lose its function. A misfolded protein can be dangerous, even fatal, to a biological organism. Thus the ability to accurately describe and control the structure and dynamics of proteins is a problem of utmost importance for biology, pharmacy, and health sciences.

 There are powerful all-atom level computational molecular dynamics techniques developed to model biological macromolecules, to describe the way how a protein folds and the way how proteins interact with each other. The simulations are performed with the highest precision accessible and using the best computational power available, including both commercial and special purpose supercomputers. However, the task is computationally enormous: even the most powerful computer available today for all-atom  dynamics can at most cover a few microseconds of in vitro folding trajectory per a day in silico, and only in the case of a relatively short protein chain. At the same time it takes several seconds, sometimes even days, for a protein to fold into its biologically active conformation, inside a living organism.

 

The enormous computational task of modeling proteins and their dynamics has prompted the development of various coarse grained force fields, where the all-atom level interactions are systematically approximated by effective interactions, using a variety of techniques. Owing to the reduction of representation and averaging of fine-grain degrees of freedom, coarse-grained molecular dynamics enables us to extend the time scale of simulations by 4 and more orders of magnitude compared to all-atom treatment. At the same time, the problem of convergence of the coarse-grained simulations can be addressed by known well-developed techniques in theoretical physics, such as Landau-Wilson approach, originally developed to describe phase transitions and critical phenomena. Alternative approaches make it possible to introduce and utilise various new approximation techniques, such as an expansion in terms of slowly varying fields (small momentum/derivative expansions). Accordingly the goal of the workshop will be to find out, whether the powerful arsenal introduced in modern mathematical and theoretical physics, including the Landau-Wilson approach with ensuing geometry and topology, could be developed to understand why and how a protein folds the way it does.


In terms of the format the goal of the workshop is to organize a stimulative environment for the discussion of principle problems in proteins dynamics and contribute to the development of new techniques to approach them. It is expected that the joint participation of specialists in physics, math, chemistry and biology will increase the efficiency of the proposed meeting and lead to the generation of new interesting ideas in each field separately.

 

The event will be focused on, but not limited to, the following list of topics:

  • Phenomenology of proteins – structures vs physical/chemical/biological properties
  • Energy functions for protein folding and dynamics – all-atoms and beyond
  • Coarse graining
  • Universality – scaling properties and structural building blocks (protein solitons)
  • Computational challenges – what can lattice QCD give to proteins
  • Protein dynamics and energy landscapes
  • Knots in proteins – how they form

 

Program

 

Check this webpage for program updates.

 

The program will include the main conference on the week of June 19 to 23, when the most participation is expected. The details of the conference program can be found at the bottom of this page.

 

Besides the conference minicourses for graduate students on protein research are planned together with a post-conference workshop. The current program of minicourses includes

 

June 12 to 16

  • Diego Ferreiro "Frustration in proteins"
  • Angel Garcia "Modeling proteins under extreme conditions "
  • Victor Muñoz -- minicourse on experimental studies of protein folding and stability
  • Piotr Sulkowski and Joanna Sulkowska "Knots in proteins"

June 19 to 23

  • Paul Whitford -- structure-based model workshop

June 26 to 30

  • Hue Sun Chan -- set of 3 lectures on aspects of protein folding.

Poster session is planned for June 19.

 

 Talk titles and abstracts (if available) can be accessed at the bottom of this page.

 

List of speakers
  • Antonio Pereira de Araujo (University of Brasilia, Brazil)
  • Ugo Bastolla (Center of Molecular Biology - UAM, Spain)
  • Hue Sun Chan (University of Toronto, Canada)
  • Vinicius Contessoto (State University of Sao Paulo - UNESP, Brazil)
  • Cezary Czaplewski (Iniversity of Gdansk, Poland)
  • Pawel Dabrowski-Tumanski (University of Warsaw, Poland)
  • Laurent Dardenne (National Laboratory of Scientific Computation - LNCC, Brazil)
  • Olga Dudko (University of California - San Diego, USA)
  • Diego Ferreiro (University of Buenos Aires, Argentina)
  • Angel Garcia (Los Alamos National Laboratory, USA)
  • Kingshuk Ghosh (University of Denver, USA)
  • Valentin Gordeliy (Eber Institute of Structural Biolology, France & ICS - Research Center Juelich, Germany)
  • Alexander Gorsky (Insitute of Information Transmission Problems, Russia)
  • Konrad Hinsen (Center of Molecular Biophysics - CNRS - Orleans, France)
  • Alexander Molochkov (Far Eastern Federal University, Russia)
  • Victor Muñoz (University of California - Merced, USA)
  • Thomas Needham (Ohio State University, USA)
  • Leandro Cristante de Oliveira (UNESP - Rio Preto, Brazil)
  • Ronaldo Junio Oliveira (Federal University of Triangulo Mineiro, Brazil)
  • Jose Onuchic (Rice University, USA)
  • Garegin Papoian (University of Maryland, USA)
  • Rodrigo Romcy-Pereira (Brain Institute, Brazil)
  • Jennifer Ross (University of Massachusetts - Amherst, USA)
  • Adam Sieradzan (University of Gdansk, Poland)
  • Joanna Sulkowska (University of Warsaw, Poland)
  • Piotr Sulkowski (University of Warsaw, Poland)
  • Paul Whitford (Northeastern University, USA)
  • Michael Woodside (University of Alberta, Canada)

 

Registration

In order to assist the organizing staff to timely issue invitation and visa letters, book accommodation and communicate important information, the prospective particpants are kindly asked to regsiter by clicking on the "Register" button at the top of this page.

 

Registration fee

The policy of the International Institute of Physics with respect to organization of events demands collecting a registration fee from the participants. The current ammount of the registration fee is set to

 

400 Brazilian reals for students;

800 Brazilian reals for professionals.

 

Registration deadline: May 14, 2017
 

Location


The city of Natal is located at the north-eastern part of Brazil, closest to Africa and Europe. Home of sandy dunes and magnificent beaches, it is an attractive destination for South American and, more recently, European tourists. We recommend to visit the Wikipedia page of Natal for general information about the city.

 

The event will take place in the new building of the International Institute of Physics on the campus of the Federal University of Rio Grande do Norte (UFRN) in Natal. The participants will have access to the facilities of the IIP, including auditorium, offices, seminar rooms and discussion rooms.

 


Accommodation and Transportation

 

We expect the participants to select their preferred accommodation type. For those participants staying for a short period (up to two weeks) the reasonable choice of the accommodation would be a room in the hotel. In the case of a longer stay, it is advisable to rent an apartment. The recommended location for the accommodation of the IIP guests is Ponta Negra, the coastal district of Natal. Both hotel and apartment reservations can be made through the organizing committee. During the program a bus transportation will be organized from one of the hotels in Ponta Negra to the IIP building.

 

Other practical information:

 
Visa: Please check whether you require a tourist visa to travel to Brazil. Nationals of the majority of European countries do not require a visa to enter Brazil as a tourist. Nationals of the USA, Canada, China, India and some other contries need to apply for a tourist visa. Please check the website of the Brazilian consulate nearest to you for the list of required documents. The IIP will be happy to assist you with the application process.

Flights: Natal has a regular flight connection with Lisbon, Portugal, operated by the Portuguese TAP. For those, coming through Europe, this is typically the most convenient option. The majority of flights operated from North America have connections in either Rio de Janeiro, or Sao Paulo. The closest direct flights (Americal Airlines from Miami and Copa Airlines from Panama City) arrive to Recife, 315 km away from Natal.

Airport: The two recommended ways to get to/from the airport is taxi and shuttle. Taxi ride from the airport to Ponta Negra will be around 80-150 reals, depending on the time of the day and traffic. Many commercial companies also operate shuttle service to/from the airport. The shuttle cost is around 35-50 reals one way and you will share the ride with several other passengers. Depending on the number of passengers it can take longer to arrive to your destination.  Uber also offers its services in Natal, in particular, connecting the city and the airport. Rates may vary depending on demand.
 
 
For more information, please contact our events department at: events@iip.ufrn.br
EVENT PROGRAM
Print this program
Date Time Speakers Name Talk Title

Tuesday

June 13, 2017

09:00 am - 10:00 am

Angel Garcia

Invited speaker

Los Alamos National Laboratory

10:00 am - 10:30 am

Coffee break

10:30 am - 11:30 am

Diego Ferreiro

Invited speaker

University of Buenos Aires

12:00 pm - 02:00 pm

Lunch

02:00 pm - 03:00 pm

Diego Ferreiro

Invited speaker

University of Buenos Aires

03:30 pm - 04:00 pm

Coffee-break

Wednesday

June 14, 2017

09:00 am - 10:00 am

Angel Garcia

Invited speaker

Los Alamos National Laboratory

10:00 am - 10:30 am

Coffee break

10:30 am - 11:30 am

Diego Ferreiro

Invited speaker

University of Buenos Aires

12:00 pm - 02:00 pm

Lunch

02:00 pm - 03:00 pm

Diego Ferreiro

Invited speaker

University of Buenos Aires

03:00 pm - 03:30 pm

Coffee-break

Thursday

June 15, 2017

09:00 am - 10:00 am

Victor Munoz

Invited speaker

Universit of California

10:00 am - 10:30 am

Coffee break

10:30 am - 11:30 am

Angel Garcia

Invited speaker

Los Alamos National Laboratory

12:00 pm - 02:00 pm

Conference Lunch

Friday

June 16, 2017

09:00 am - 10:00 am

Victor Munoz

Invited speaker

Universit of California

10:00 am - 10:30 am

Coffee break

10:30 am - 11:30 am

Piotr Sulkowski

Invited speaker

University of Warsaw

12:00 pm - 02:00 pm

Lunch

02:00 pm - 03:00 pm

Victor Munoz

Invited speaker

Universit of California

03:00 pm - 03:30 pm

Coffee-break

03:30 pm - 04:30 pm

Joanna Sulkowska

Invited speaker

University of Warsaw

Monday

June 19, 2017

09:00 am - 10:00 am

Gerald Kneller

Invited speaker

University of Orléans

10:00 am - 10:30 am

Coffee break

10:30 am - 11:15 am

Ugo Bastolla

Invited speaker

Universidad Autonoma de Madrid

11:15 am - 12:00 pm

Piotr Sulkowski

Invited speaker

University of Warsaw

12:00 pm - 02:00 pm

Lunch

02:00 pm - 02:45 pm

Konrad Hinsen

Invited speaker

Centre de Biophysique Moléculaire in Orléans

02:45 pm - 03:30 pm

Pawel Dabrowski

Invited speaker

Centre of New Technology

03:30 pm - 04:00 pm

Coffee-break

04:00 pm - 04:45 pm

Garegin Papoian

Invited speaker

University of Maryland

05:00 pm - 06:00 pm

Poster session

Tuesday

June 20, 2017

09:00 am - 10:00 am

Garegin Papoian

Invited speaker

University of Maryland

10:00 am - 10:30 am

Coffee break

10:30 am - 11:15 am

Cezary Czaplewski

Invited speaker

University of Gdansk

11:15 am - 12:00 pm

Victor Munoz

Invited speaker

Universit of California

12:00 pm - 02:00 pm

Lunch

02:00 pm - 02:45 pm

Laurent Dardenne

Invited speaker

National Laboratory of Scientific Computation - LNCC

02:45 pm - 03:30 pm

Joanna Sulkowska

Invited speaker

University of Warsaw

03:30 pm - 04:00 pm

Coffee-break

04:00 pm - 05:00 pm

Jose Nelson Onuchic

Invited speaker

Rice University

Wednesday

June 21, 2017

09:00 am - 10:00 am

Paul Whitford

Invited speaker

Northeastern University

10:00 am - 10:30 am

Coffee break

10:30 am - 11:15 am

Thomas Needham

Invited speaker

Ohio State University

11:15 am - 12:00 pm

Angel Garcia

Invited speaker

Los Alamos National Laboratory

12:00 pm - 02:00 pm

Lunch

02:00 pm - 02:45 pm

Adam Sieradzan

Invited speaker

University of Gdansk

02:45 pm - 03:30 pm

Alexander Gorsky

Invited speaker

IITP, Moscow

03:30 pm - 04:00 pm

Coffee-break

04:00 pm - 05:00 pm

Rodrigo Romcy Pereira

Invited speaker

Brain Institute

05:00 pm - 05:45 pm

Paul Whitford

Invited speaker

Northeastern University

07:30 pm - 10:00 pm

Conference Dinner

Thursday

June 22, 2017

09:00 am - 10:00 am

Hue Sun Chan

Invited speaker

University of Toronto

10:00 am - 10:30 am

Coffee break

10:30 am - 11:15 am

Olga Dudko

Invited speaker

University of California, San Diego

11:15 am - 12:00 pm

Kingshuk Ghosh

Invited speaker

University of Denver

12:00 pm - 02:00 pm

Lunch

02:00 pm - 02:45 pm

Antonio Francisco Pereira de Araujo

Invited speaker

University of Brasilia

02:45 pm - 03:30 pm

Adam Liwo

Invited speaker

University of Gda?sk

03:30 pm - 04:00 pm

Coffee-break

04:00 pm - 05:00 pm

Valentin Gordeliy

Invited speaker

J.-P. Ebel Institute of Structural Biology & Institute of Complex Systems (ICS), Research Centre Juelich

05:00 pm - 05:45 pm

Paul Whitford

Invited speaker

Northeastern University

Friday

June 23, 2017

09:00 am - 10:00 am

Michael Woodside

Invited speaker

University of Alberta

10:00 am - 10:30 am

Coffee break

10:30 am - 11:15 am

Alexander Molochkov

Invited speaker

Far Eastern Federal University

11:15 am - 12:00 pm

Ronaldo J. Oliveira

Invited speaker

Federal University of Triangulo Mineiro

12:00 pm - 02:00 pm

Lunch

02:00 pm - 03:30 pm

Paul Whitford

Invited speaker

Northeastern University

03:30 pm - 04:00 pm

Coffee-break

Monday

June 26, 2017

09:30 am - 10:30 am

Hue Sun Chan

Invited speaker

University of Toronto

10:00 am - 10:30 am

Coffee break

11:00 am - 12:00 pm

Michael Woodside

Invited speaker

University of Alberta

12:00 pm - 02:00 pm

Lunch

02:00 pm - 03:00 pm

Vinícius Contessoto

Invited speaker

Brazilian Bioethanol Science and Technology Laboratory (CTBE)

03:00 pm - 03:30 pm

Coffee-break

Tuesday

June 27, 2017

09:00 am - 10:00 am

Hue Sun Chan

Invited speaker

University of Toronto

10:00 am - 10:30 am

Coffee break

11:00 am - 12:00 pm

Leandro Cristante de Oliveira

Invited speaker

UNESP - Rio Preto

12:00 pm - 02:00 pm

Lunch

Wednesday

June 28, 2017

09:00 am - 10:00 am

Hue Sun Chan

Invited speaker

University of Toronto

10:00 am - 10:30 am

Coffee break

12:00 pm - 02:00 pm

Lunch